Coordination of Rheb lysosomal membrane interactions with mTORC1 activation
نویسندگان
چکیده
منابع مشابه
Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.
Ras homolog enriched in brain (Rheb) is a small GTPase that regulates cell growth, differentiation, and survival by upregulating mammalian target of rapamycin complex 1 (mTORC1) signaling. The role of Rheb/mTORC1 signaling in the activation of kidney fibroblasts and the development of kidney fibrosis remains largely unknown. In this study, we found that Rheb/mTORC1 signaling was activated in in...
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The signalling function of mTOR complex 1 is activated by Rheb-GTP, which controls the catalytic competence of the mTOR (mammalian target of rapamycin) kinase domain by an incompletely understood mechanism. Rheb can bind directly to the mTOR kinase domain, and association with inactive nucleotide-deficient Rheb mutants traps mTOR in a catalytically inactive state. Nevertheless, Rheb-GTP targets...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2020
ISSN: 2046-1402
DOI: 10.12688/f1000research.22367.1